Cannabinoids(CBDs) are the chemical signals for the endocannabinoid system. CBDs fall under two categories: endogenous or exogenous.
Endogenous means originating inside the body, compounds are produced naturally by your body. They regulate basic functions including mood, memory, appetite, pain, sleep, and many more.
Exogenous means originating outside the body. The CBDs in marijuana, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), are exogenous. They also interact with cannabinoid receptors to produce physical and psychological effects in the body.
Cannabinoid receptors receive chemical messages and produce an effect on your body. Two types of receptors are present in the body:
- CB1: are found throughout your body with a concentration in the brain and spinal cord. These receptors have an effect on behaviors and sensations such as pain and anxiety.
- CB2: are found in the peripheral nervous system. These receptors can be found in cells that are in the Immune system, reducing inflammation.
CBD will not produce a "high!" Different theories exist about how CBD works in the body:
Theory 1: CBD inhibits an enzyme called FAAH, which is responsible for the breakdown of anandamide . When FAAH is inhibited, it cannot break down anandamide at its normal rate. This leads to a buildup of anandamide in the brain.
Theory 2: Clinical Endocannabinoid Deficiency (CECD) states that a deficiency exists in the endocannabinoidal levels that causes certain medical conditions, like migraines, irritable bowel syndrome, fibromyalgia.
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Research sites:
https://www.healthline.com/health/endocannabinoid-system
https://www.leafscience.com/2017/03/17/the-endocannabinoid-system-a-beginners-guide/
https://www.mayoclinicproceedings.org/action/showPdf?pii=S0025-6196%2819%2930007-2